Endocrine Abstracts

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

Introduction: Research into autoimmune disorders associated with COVID-19 in the middle of an ongoing COVID-19 pandemic is an important and urgent challenge. We focus on the potential relationship between coronavirus infection and other autoimmune diseases, and the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs traditionally used in the treatment of rheumatological diseases. The results of this study are a starting point for understanding t...

Pregnant women are at risk of developing diseases associated with deficiency of essential micronutrients.Objective: To assess the prevalence of vitamin D deficiency among pregnant women and its dependence on the trimester of pregnancy.Methods: We examined 476 pregnant women at different gestational periods from three regions of Russia (Moscow, Ivanovo, Smolensk). Concentration of 25(OH)vitamin D (ng/ml) was estimated by immunometri...

According to numerous studies, type 2 diabetes mellitus (T2DM) is associated with an increased risk of low traumatic non-vertebral fracture. There are a limited number of studies which evaluate lateral vertebral X-Rays in order to diagnose vertebral fractures in patients with T2DM. The goal of our study was to investigate the difference in vertebral fracture rate registered on lateral X-Ray between subjects with T2DM and a control group being under observation in the same outp...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are associated with cardiovascular diseases (CVD). Fibrotic changes in obesity include several molecular processes, including activation of Transforming growth factor β (TGF-β). Recent data indicate the involvement of Fibroblast growth factor 21 (FGF-21) as an important metabolic regulator, and even biomarker of metabolic changes in obesity and T2DM.Aim: To determine TGF-β and FGF-2...

Introduction: One of the manifestations of Munchausen syndrome is the deliberate injection of insulin to achieve hypoglycemia or artificial hypoglycemia. If human insulin is injected, we will always determine high level of insulin and low level of Cpeptideatthemomentofhypoglycemia. Incasesof insulin analogues injection the diagnos is maybe difficult when we use analyzers specific only to human insulin: the low level of IRI and C peptide will be determined.<p class="abstext...

Introduction: One of the autoimmunenon-diabetic hypoglycemia (NDH) causes isthe antibodies to insulinreceptor (AB-rIRI) formation and/orinsulin resistance type B (TBIR).Objectives: To determine the prevalence of increased AB-rIRI level in patients with suspected NDH of different genesis and in healthy individuals; to determine significance of AB-rIRI investigation in NDH diagnosis.Methods: In a prospective study we determined AB-rI...

Introduction: One of the autoimmune non–diabetic hypoglycemia (NDH) causes is the formation of antibodies to insulin (AB–IRI) or Hirata disease (HD).Objectives: To determine the prevalence of AB–IRI level increasing in patients with suspected NDH of various genesis and in healthy individuals.Methods: 96 patients aged 18–80 years with suspected NDH were included in prospective study. In all patients we determ...

Introduction: This problem has a major social and medical significance. The prevalence of secondary endocrine hypertension is around 40%, of which primary aldosteronism is up to 15% and is usually developed at working age. Despite of improvement of diagnostical two-step method of finding primary aldosteronism, none of these test results can be considered reliable because of false positive and false negative results. That’s why the problem of endocrine hypertension diagnos...

Introduction: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hypotonic and euvolemic hyponatremia along with urinary hyperosmolarity, resulting from antidiuretic hormone (ADH) release in the absence of adequate stimuli.Case report: A 59-year-old woman, presented with complaints of constant thirst, general weakness, memory loss, episodes accompanied by headaches, leg cramps, increased blood pressure. From the a...